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Innovative therapies, such as recombinant factor VIII (FVIII), have reduced the burden of haemophilia for patients and their families. We investigated the economic impact of home-based recombinant FVIII (Baktavax; Baxter Healthcare, Vienna, Austria) therapy in patients with severe haemophilia A. Using data from two clinical studies, we estimated a mean annual direct medical cost for patients treated with home-based recombinant FVIII (Baktavax) therapy of 2,506.5 euro per patient. Excluding indirect costs, the mean annual cost per patient ranged between 646.3 and 1,826.9 euro. The mean annual indirect costs were 379.8 euro per patient. We concluded that home-based recombinant FVIII (Baktavax) therapy is associated with a significant decrease in direct and indirect costs compared with prophylactic treatment. Home-based therapy also allowed a larger portion of patients to be treated with a lower inhibitor risk and a lower dose of inhibitor eradication therapy. This study provides an estimate of the economic impact of home-based recombinant FVIII (Baktavax) therapy for patients with severe haemophilia A.The government has shut down one of the most popular government websites in the country, and experts say this may have been the work of foreign hackers.
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